Chemical and Bio-sensors a Multilayer Optical Test Strip for Copper Determination in Human Plasma

نویسندگان

  • L. F. Capitán-Vallvey
  • C. Cano-Raya
  • C. Esparza del Valle
  • M. D. Fernández Ramos
  • I. de Orbe-Payá
  • R. Avidad
  • V. Ramı́rez González
چکیده

A new procedure to determine copper has been proposed using an irreversible and disposable multilayer optical test strip. Two layers form the sensing zone: a copper sensitive and a dialysis layer. The test strip is characterised to be a disposable polyester sheet contained in a circular film 6mm in diameter and 25 mm in thickness, with all reagents necessary to produce a selective response. The sensing zone was formed by Nafion as polymer, bathocuproine as a chromogenic reagent and p-anisidine as reducer. When it is applied to determination of copper in plasma samples, another layer of hydrogel D-6 is put on this membrane to eliminate the inter-

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تاریخ انتشار 2002